Preparation and Characterization of Magnetoconductive Composite Scaffold for Neural Tissue Engineering

Tissue engineering of peripheral nerves has gain an increasing interest in regenerative medicine. Culturing neural cells on magnetoconductive scaffolds, due to their combination of magnetic and electrical properties, promotes their proliferation and differentiation. In this study a novel composite scaffold based on iron oxide-polyaniline/chitosan-gelatin (Fe۳O۴-PANI/CS-Gel) was developed. The synthesized Fe۳O۴-PANI composite was characterized using FTIR, XRD, electrical conductivity and magnetic properties. Also, the effects of Fe۳O۴ and PANI on the properties of CS-Gel scaffolds were investigated. The composite scaffold was highly porous with the pore size of ۱۰۰-۳۰۰ μm. The results showed that the mechanical properties were increased by the Fe۳O۴-PANI loading, while the porosity, swelling ratio and in vitro biodegradability were decreased. This work supports the use of a magnetoconductive scaffold with a low amount of Fe۳O۴-PANI, ۰.۳۵ wt. %, as a suitable material having proper properties that may be appropriate for scaffold in tissue engineering for neural repair.

کلیدواژه ها:

Magnetoconductive ، Scaffold ، Nerve ، Tissue Engineering