Cardioprotective and Hepatoprotective Activity of Silymarin in BroilerChickens Fed on Mash and Pellet Diets

  BACKGROUND: The liver and heart are two main damaged organs in ascites syndrome in fast -growing broilers. Using silymarin with a protective effect on the liver and heart may be a beneficial strategy to decrease ascites-induced mortality. OBJECTIVES: The present study assessed the cardiohepatic effects of silymarin in broilers fed on mash and pellet diets by assessing electrocardiographic (ECG) indices and some serum biochemical parameters. METHODS: A total of ۱۲۰ Arbor Acres chicks were allocated to ۶ groups and treated as follows: basal mash diet (CM); basal pellet diet (CP); silymarin at ۵۰۰ ppm of mash (M۵۰۰) and pellet diets (P۵۰۰); and silymarin at ۲۵۰۰ ppm of mash (M۲۵۰۰) and pellet diets (P۲۵۰۰). RESULTS: CP had higher serum activities of aspartate aminotransferase, alanine aminotransferase, and creatine kinase MB (CK-MB) enzymes compared to CM (p <۰.۰۵). P۲۵۰۰ had a higher total protein and lower aspartate aminotransferase, alanine aminotransferase, and CK-MB compared to CP (p <۰.۰۵). T-duration, ST-segment, and R-R intervals were longer in CP compared to CM and were shorter in P۲۵۰۰ than in CP and P۵۰۰ (p <۰.۰۵). CONCLUSIONS: The pellet diet led to changes in some biochemical and ECG indices in broilers, and silymarin at the ۲۵۰۰ ppm dose can be used as a hepatoprotective and cardioprotective compound to modulate cardiohepatic failure in susceptible broilers.

کلیدواژه ها:

.Cardiac evaluation ، Hepatic evaluation ، Mash diet ، Pellet diet ، Silymarin