Effect of ethanol stem extract of homalium letestui on gentamicin-induced kidney Injury in rat
محل انتشار: دوفصلنامه طب گیاهی پیشرفته، دوره: 4، شماره: 2
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 299
فایل این مقاله در 14 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_JHPH-4-2_006
تاریخ نمایه سازی: 11 خرداد 1400
چکیده مقاله:
Background and aims: The kidney is a very vital organ that is responsible for regular elimination of unwanted substances from the body. It is frequently exposed to conditions that expose it to damage. There are not enough drugs in the market to protect or treat the kidney against these deleterious conditions. Homalium letestui has been used in traditional medicine as an antidote. This study aims to investigate the nephroprotective activity of ethanol stem extract of Homalium lestetui against gentamicin-induced rat’s kidney injury. Methods: Thirty-six (۳۶) adult male albino rats were used for this study. Animals in group I served as the control with normal saline, group II received gentamicin (۱۰۰ mg/kg), group III received Silymarin (۱۰۰ mg/kg), while group IV, V and VI where administered ۲۵۰, ۵۰۰ and ۷۵۰ mg/kg of ethanol stem extract of Homalium letestui along with gentamicin ۱۰۰ mg/kg for ۸ days. The nephroprotective effect of the extract was evaluated by the assay of kidney function parameters such as serum urea, creatinine, electrolytes (K+, Na+, Cl- and HCO-۳) and histopathological examination of the kidney. Results: Homalium letestui caused significant p≤ ۰.۰۵ dose-dependent reduction in the level of serum urea, creatinine, and electrolytes in rat’s kidney when compared to the control. The chemical pathological changes were consistent with histopathological observations suggesting marked the nephroprotective effect of the stem extract of H. letestui. Conclusion: The result of the study suggests that the plant has kidney protective ability which supports its traditional use as an antidote
کلیدواژه ها:
نویسندگان
simeon joseph
Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Gombe State University, Gombe State, Nigeria.
JUDE OKOKON
UNIVERSITY OF UYO, UYO, NIGERIA
opeyemi joseph
Department of Pharmacology, Faculty of Pharmacy, University of Port Harcourt, Nigeria.
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :