The effect of royal jelly and silver nanoparticles on liver and kidney inflammation

سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 401

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شناسه ملی سند علمی:

JR_AJP-11-3_002

تاریخ نمایه سازی: 8 خرداد 1400

چکیده مقاله:

Objective: Royal jelly (RJ) is a honey bee product for which, anti-inflammatory properties were shown in vitro. Nanoparticles, including nano-silver (NS), are plausible inflammation inducers that act by activation of immune cells and consequent production of pro-inflammatory cytokines. This project aimed to explore immunomodulatory effects of royal jelly and nano-silver on the kidney and liver. Materials and Methods: In this project, ۴۰ male rats were grouped as follows: ۱۰ rats as controls, ۱۰ rats treated with RJ; ۱۰ rats treated with both NS and RJ and ۱۰ rats treated with NS. Liver and kidney interleukin (IL)-۱β, -۲, -۶, and -۳۳ levels were determined using commercial ELISA kits. Results: RJ reduced kidney IL-۶ levels in comparison to control and NS--RJ groups. RJ and NS reduced kidney and liver IL-۱β levels. Kidney IL-۳۳ levels were decreased in the RJ and nano-silver groups in comparison to the NS--RJ group. Conclusion: Based on this study, it may be concluded that RJ together with NS can play anti-inflammatory roles and may affect the function of immune cells.

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نویسندگان

Hossein Pourmobini

Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences

Mohammad Kazemi-arababadi

Department of Immunology, Faculty of Medicine, Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Mohammad Reza Salahshoor

Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran

Shiva Roshankhah

Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran

Mohammad Mohsen Taghavi

Department of Anatomy, Faculty of Medicine, Social Determinants of Health Research center Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Zahra Taghipour

Department of Anatomy, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Ahmad Shabanizadeh

Department of Anatomy, Faculty of Medicine, Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran