The effect of royal jelly and silver nanoparticles on liver and kidney inflammation

Objective: Royal jelly (RJ) is a honey bee product for which, anti-inflammatory properties were shown in vitro. Nanoparticles, including nano-silver (NS), are plausible inflammation inducers that act by activation of immune cells and consequent production of pro-inflammatory cytokines. This project aimed to explore immunomodulatory effects of royal jelly and nano-silver on the kidney and liver. Materials and Methods: In this project, ۴۰ male rats were grouped as follows: ۱۰ rats as controls, ۱۰ rats treated with RJ; ۱۰ rats treated with both NS and RJ and ۱۰ rats treated with NS. Liver and kidney interleukin (IL)-۱β, -۲, -۶, and -۳۳ levels were determined using commercial ELISA kits. Results: RJ reduced kidney IL-۶ levels in comparison to control and NS--RJ groups. RJ and NS reduced kidney and liver IL-۱β levels. Kidney IL-۳۳ levels were decreased in the RJ and nano-silver groups in comparison to the NS--RJ group. Conclusion: Based on this study, it may be concluded that RJ together with NS can play anti-inflammatory roles and may affect the function of immune cells.