Effect of pantoprazole on I-R -induced myocardial injury in diabetic rats targeting inflammatory cytokine release and oxidative stress

Objective(s): To evaluate the pleiotropic potential and underlying mechanism of pantoprazole (PPZ) (common Proton Pump Inhibitors, PPIs) in type ۲ diabetes mellitus (T۲DM) -associated ischemia/reperfusion (I-R)-induced myocardial infarction which is still uncharted. Whereas some other PPIs have demonstrated their anti-diabetic, antioxidant, and anti-inflammatory potential. Materials and Methods: We evaluated the potential of coinciding treatment of PPZ (۴ mg/kg/po/day for ۸ weeks) in Wistar albino rats against STZ (۵۰ mg/kg/IP) induced T۲DM model and I-R provoked cardiac infarction model in diabetic and non-diabetic condition. Results: PPZ significantly inhibited the perturbed deviations in blood glucose concentration, HbA۱c, C-peptide, plasma insulin, and ameliorated the lipid profile (dyslipidemia). PPZ protected myocardial tissue against lipid peroxidation by restoring the levels of serum TBARS and reduced NBT. The significant protective effects of PPZ were evident by ameliorating CKMB, LDH, cTnI, and myocardial oxidative stress in PPZ treated animals. Additionally, PPZ prominently reduced various proinflammatory cytokines release including TGF-β۱, TNF-α, and IL-۶. PPZ upsurges the bioavailability of nitrite/nitrate concentration which may pacify the impact of myocardial infarction in diabetic I-R injury. Conclusion: The consequences indicate that PPZ possesses a potent protective effect against diabetic I-R-induced myocardial infarction via suppressing oxidative stress, inflammation, and dyslipidemia-associated tissue damage.

کلیدواژه ها:

Cardiomyopathy ، Diabetes Mellitus ، Inflammatory cytokines ، Myocardial I/R insult ، Oxidative stress ، Pantoprazole