Correlations of Maternal Serum Zinc Levels with Cord Blood Procollagen Type ۱-N Terminal Propeptide Levels and Anthropometric Measurements of Newborns

Background: Zinc is an important micronutrient that is required for optimal fetal growth and development. Zinc deficiency during pregnancy may interfere with intrauterine fetal ossification. Fetal ossification can be measured with specific bone growth markers, such as procollagen type ۱-N terminal propeptide (P۱NP). This study aimed to investigate the mean maternal serum zinc levels and assess the correlations of maternal serum zinc levels with cord blood P۱NP levels and anthropometric measurements of newborns. Methods: This cross-sectional study was conducted at Universitas Sumatera Utara Hospital and other hospitals in Medan, Indonesia, from April to October ۲۰۱۹. The statistical populations were pregnant mothers and their newborns who met the inclusion criteria. The participants were selected using a consecutive sampling technique. Maternal serum zinc levels and cord blood P۱NP levels were measured before delivery; moreover, anthropometric measurements were conducted in this study. Results: A total of ۴۲ subjects were included in this study with a mean maternal serum zinc level of ۵۲.۰±۹.۰ µg/dL. The proportion of pregnant mothers with low serum zinc levels was high (۵۴.۸%). According to the results, there was a significant correlation between maternal serum zinc levels and newborn birth weight (r=۰.۶۴۸) and length (r=۰.۶۵۶), as well as head circumference (r=۰.۵۷۸; P=۰.۰۰۱). There was also a significant and positive linear correlation between maternal serum zinc levels and cord blood P۱NP levels (r=۰.۴۶۹; P=۰.۰۰۲). Conclusion: The mean maternal serum zinc levels during pregnancy were below normal. There were positive significant correlations between maternal serum zinc levels and cord blood P۱NP levels with anthropometric measurements of newborns.    

کلیدواژه ها:

Anthropometrics of newborns ، Cord blood P۱NP ، Maternal serum zinc