Assessment of MTHFR gene promoter methylation pattern in essential hypertensive patients
سال انتشار: 1399
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 305
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شناسه ملی سند علمی:
CIGS16_035
تاریخ نمایه سازی: 14 اردیبهشت 1400
چکیده مقاله:
Background and Aim: Methylenetetrahydrofolate reductase (MTHFR) is a major enzyme in the metabolism of homocysteine. Hyperhomocysteinemia is associated with essential hypertension. This study aimed to investigate the possible association of MTHFR gene promoter methylation with the development of essential hypertension. Methods: ۲۰ confirmed hypertensive patients and ۲۰ healthy matched controls were selected from Shaheed Mohammadi Hospital, Hormozgan University of medical sciences, Iran. DNA methylation levels of ۱۰ CpG dinucleotides on MTHFR gene promoter were measured using bisulfite sequencing method.Results: Our results show no significant differences in the methylation profile of the promoter region of MTHFR gene between patients and control group. Also MTHFR gene promoter methylation in male and female patients show the same pattern.Conclusion: Our results indicate that methylation status of MTHFR gene promoter had no significant association with primary hypertension.
کلیدواژه ها:
نویسندگان
Shabnaz Koochakkhani
Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Ebrahim Eftekhar
Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences,Bandar Abbas, Iran
Fatemeh Nabizadeh
Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences,Bandar Abbas, Iran
Abdolazim Nejatizadeh
Cardiovascular research Center, Hormozgan university of medical sciences, Bandar Abbas, Iran