A Systematic Review and Meta-Analysis of the Safety and Effectiveness of Tenecteplase Versus Alteplase in Treatment of Patients with ST-Elevation Myocardial Infarction
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 187
فایل این مقاله در 11 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_ZUMS-28-130_005
تاریخ نمایه سازی: 11 اردیبهشت 1400
چکیده مقاله:
thrombolytic therapy, an appropriate treatment option , if primary angioplasty is not available for the treatment of Acute Myocardial Infarction patients in the early hours after the onset of the symptoms. The aim of this study was to evaluate the safety and effectiveness of the tenecteplase drug vs alteplase in the treatment of STEMI patients. We searched the PubMed, cochrane library, Web Of Science for safety and clinical effectiveness. we hand searched US, european, and iranian cardiovascular journals. Randomized clinical trials that included comparison TNKase with alteplase drugs alone OR with other drugs in STEMI patients in English, Persian and Korean languages were selected in this study. Two review authors independently assessed RCTs studies eligibility and quality. Finally, the data were analysis with Review Manager v ۵.۳. there was no statistically significant difference between tenecteplase and alteplase in risk of ۳۰ day mortality(RR=۱.۰۱;۹۵% CI:۰.۸۹-۱.۱۳, p=۰.۸۲).the risk of Reinfarction, cardiogenic shock ,ICH, stroke and minor bleeding were similar in AMI patients treated With both drugs. tenecteplase was associated with a statistically significant reduction total bleeding and major bleeding , Respectively (p=۰.۰۰۰۳)and(p=۰.۰۰۰۳). tenecteplase in comparison with alteplase is recommended due to the easier use and better safety in reducing the risk of bleeding.
کلیدواژه ها:
نویسندگان
Salman Bashzar
Student Research Committee, School of Health Management and Information Sciences, Kerman University of Medical Sciences, Kerman, Iran
Shekoufeh Nikfar
Dept. of Pharmacoeconomics, Faculty of Farmacy, Tehran University of Medical Sciences, Tehran, Iran
Asma Sabermahani
Student Research Committee, School of Health Management and Information Sciences, Kerman University of Medical Sciences, Kerman, Iran
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :