Study of Antioxidant Status and Oxidative Stress in Diabetic Rats Treated with Royal Jelly

سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 174

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شناسه ملی سند علمی:

JR_ZUMS-25-111_007

تاریخ نمایه سازی: 11 اردیبهشت 1400

چکیده مقاله:

Background and Objective: Diabetes mellitus is one of the most common metabolic disorders worldwide. Numerous natural compounds have been developed to treat diabetes mellitus. Royal jelly (RJ) has antioxidant and antidiabetic properties. This study was carried out to investigate the effects of RJ on antioxidant status, lipid peroxidation and liver tissue in diabetic rats. Materials and Methods: In this experimental study, ۳۲ adult male Wistar rats (۱۹۰-۲۰۰ gr) were randomly divided into ۴ groups including control, royal jelly, diabetic and diabetic treated with royal jelly. Diabetes was induced by intraperitoneal injection of streptozotocin (۵۰ mg/kg) and Royal Jelly (۱۰۰ mg/kg) was gavaged for ۴۲ days. At the end of our study, serum levels of malondialdehyde, total antioxidant capacity (TCA) and superoxide dismutase/glutathione peroxidase activity were determined spectrophotometrically, while the rat’s livers were isolated for histological study. Results: Consumption of RJ showed a significant decrease in malondialdehyde serum levels (P= ۰.۰۰۷) and a significant increase in total antioxidant capacity, superoxide dismutase (P=۰.۰۰۱۹) and glutathione peroxidase activity in the RJ treated diabetic rats compared to diabetic rats (P= ۰.۰۰۳). Administration of royal jelly improved liver histological states. Conclusion: RJ increases antioxidant power and prevents the occurrence of histopathological changes resulting from diabetes in rats.

نویسندگان

الهام قنبری

Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

عاطفه انصاریان

Dept. of Cardiology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

فروغ یوسفزایی

Dept. of Biology, Zabol University, Zabol, Iran

مظفر خزاعی

Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

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  • Tripathi BK, Srivastava AK. Diabetes mellitus: complications and therapeutics. Med ...
  • Whiting DR, Guariguata L, Weil C, Shaw J. IDF Diabetes ...
  • Mayfield J. Diagnosis and classification of diabetes mellitus: new criteria. ...
  • Tolman KG, Fonseca V, Dalpiaz A, Tan MH. Spectrum of ...
  • Moller DE. New drug targets for type 2 diabetes and ...
  • Halliwell B. Antioxidants in human health and disease. Annu Rev ...
  • Michiels C, Raes M, Toussaint O, Remacle J. Importance of ...
  • Oruç EÖ, Usta D. Evaluation o ...
  • oxidative stress responses and neurotoxicity potential of diazinon in different ...
  • Dey L, Attele AS, Yuan CS. Alternative therapies for type ...
  • Jung M, Park M, Lee HC, Kang YH, Kang ES, ...
  • Ramadana MF, Al-Ghamdib A. Bioactive compounds and health-promoting properties of ...
  • Pavel IC, Mărghitaş LA, Bobiş O, et al. Biological activities ...
  • El-Nekeety AA, El-Kholy W, Abbas NF, Ebaid A, Amra HA, ...
  • Ghanbari E, Nejati V, Azadbakht M. Protective effect of royal ...
  • Guo H, Ekusa A, Iwai K, Yonekura M, Takahata Y, ...
  • Zimmermann A. Liver regeneration: the emergence of new pathways. Med ...
  • Şimşek N, Karadeniz A, Bayraktaroğlu AG. Effects of L-carnitine, royal ...
  • cells in rats. Kafk as Univ Vet Fak Derg. 2009; ...
  • Mobasseri M, Ghiyasvand S, Ostadrahimi A, Ghojazadeh M, Noshad H, ...
  • Pourmoradian S, Mahdavi R, Mobasseri M, Faramarzi E, Mobasseri M. ...
  • Ghanbari E, Nejati V, Najafi G, Khazaei M, Babaei M. ...
  • Pakseresht Z, Norouzi P, Hojati V, Kalalian Moghaddam H. Effect ...
  • Lotfi N, Khazaei M, Shariatzadeh SM, Mehranjani MS, Ghanbari A. ...
  • Nasirzadeh MR. Pretreatment with olive leaf extract on liver injury ...
  • Amaral S, Oliveira PJ, Ramalho-Santos J. Diabetes and the impairment ...
  • Mohammadi J, Delaviz H, Malekzadeh JM, Roozbehi A. The effect ...
  • Chiş IC, Clichici S, Mureşan A, Nagy AL, Oros A. ...
  • Karadeniz A, Simsek N, Karakus E, et al. Royal jelly ...
  • Nejati V, Zahmatkesh E, Babaei M. Protective effects of royal ...
  • Malekinejad H, Fani M, Shafiee-Roodbari SK, Delkhosh-Kasmaie F, Rezaei-Golmisheh A. ...
  • Guo H, Kouzuma Y, Yonekura M. Structures and properties of ...
  • Ghosh S, Bhattacharyya S, Rashid K, Sil PC. Curcumin protects ...
  • Yildirim S, Karadeìz A, Karako A, Yildirim A, Kalkan Y, ...
  • Kanbur M, Eraslan G, Beyaz L, et al. The effects ...
  • Sheweita SA, Mashaly S, Newairy AA, Abdou HM, Eweda SM. ...
  • Cihan YB, Ozturk A, Gokalp SS. Protective role of royal ...
  • Ghanbari E, Nejati V, Khazaei M. Antioxidant and protective effects ...
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