Survey of LDL-c Diameter and sdLDL-c Serum Levels in Relation with Hypertriglyceridemic waist Circumference Phenotype in Middle Aged Women

Background and Objectives: Obesity is a major risk factor of cardiovascular diseases. Visceral adipose tissue (VAT) plays an important role in complications obesity. Although the measurement of waist circumference is a useful index for evaluating obesity and its complications, always increasing of waist circumference is not associated with VAT accumulation. HTGW (Hypertriglyceridemic waist circumference) phenotype is a useful marker for visceral adipose tissue accumulation. The purpose of this study is comparison of sdLDL-c serum level and LDL-c particle size as risk factors for cardiovascular diseases in middle aged woman with HTGW phenotype and without it. Materials and Methods: For this purpose, ۹۰ volunteer women between ۴۰ and ۶۰ years old based on the four common definitions of HTGW phenotype, were divided into two groups with and without this phenotype. It was used precipitation method for measurement of serum levels of sdLDL-c. LDL-c particle size also was measured by the gradient gel electrophoresis technique. Results: Although in all of definitions, LDL-c particle size significantly was smaller in group with this HTGW phenotype, sdLDL-c serum level was statistical significant different in both definitions of HTGW-L and HTGW-H. Conclusion: According to significant difference in diameter of LDL-c particles and sdLDL-c concentrations grouped based on the definitions HTGW-L and HTGW-H as well as the role of sdLDL-c particles in cardiovascular diseases, therefore mentioned definitions are useful inexpensive screening tools to identify individuals at risk for cardiovascular diseases. References ۱- Després J-P. Cardiovascular disease under the influence of excess visceral fat. Critical Pathways In Cardiology. ۲۰۰۷ ۶: ۵۱-۹. ۲- Sarrafzadegan N, Kopaei SA. The Association between hypertriglyceridemic waist phenotype, menopause, and cardiovascular risk factors. 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Keywords: Cardiovascular diseases ، Hypertriglycirdemia ، Waist circumference ، HTWG