Investigation of Coexistance of Human Papilloma Virus with Esophageal Squamous Cell Carcinoma in Patients Referring to Vali-e-Asr Hospital in Zanjan ۲۰۰۲-۲۰۰۳

Background: Squamous cell carcinoma (SCC) is a fatal cancer with world wide spread. Studies concerning the association of viruses specially human papilloma virus with the disease indicate contradictory results. Thus, this study was carried out to investigate the relation between human papilloma virus (HPV) and squamous cell cancer (SCC) in biopsied samples of patients in Zanjan within ۲۰۰۲-۲۰۰۳. Materials and Methods: This case - control study was carried out on biopsied esophageal samples of ۳۴ patients over ۲۵ years of age (۱۷ cases and ۱۷ controls). Biopsied samples were stained through hematoxylin and eosin methods and tested for SCC by light microscope on the basis of cytology (Presence of degenerated cells, vacuolated cell, ...) and histology (HPV). The data were analyzed through Spss software and test. Results: Of ۱۷ patients suffering from SCC ۱۱ people (۶۴.۷%) and out of ۱۷ patients without SCC ۱۳ people (۷۶.۴%) were effected by HPV indicating no significant relation. Besides, there was no significant relation between HPV and tumor location or cancer differentiation. Conclusion: We did not find a significant relation between HPV and SCC. Regarding the small sample size of the study, sensitivity and specificity of cytopathology method, further studies with more accurate techniques, like chromosome survey, cytogenetic and PCR are recommended.

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KEY WORDS: Squamous cell carcinoma (SCC) ، Human papilloma virus (HPV) ، Esophageal biopsy