Correlation between the Energy Density of Ultraviolet Radiation and Skin Thickening In an Animal Mouse Model: Induction of Trichoepithelioma in a Mouse Model

سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 456

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شناسه ملی سند علمی:

JR_IJMP-18-2_004

تاریخ نمایه سازی: 6 اردیبهشت 1400

چکیده مقاله:

Introduction: Exposure to ultraviolet (UV) radiation causes oxidative damage and cancer in the epidermis. The thickening of the skin layer seems to be correlated with carcinogenicity. The present study aimed to induce trichoepithelioma, a rare benign skin lesion, in an animal model and investigate the relationship between the radiation dose of UV waves and the thickening of skin layers resulting from high-frequency ultrasound images. Material and Methods: To investigate skin damage process, ۲۵ C۵۷BL۶ mice were irradiated with Ultraviolet B-rays (UVB) (۵ times a week for ۹ weeks) with an energy density of ۱۳۵, ۲۷۰, ۴۰۵, ۵۴۰, ۶۷۵, ۸۱۰, ۹۴۵, ۱۰۸۰, and ۱۲۱۵ J/m۲, from the first week to the ninth week, respectively. The thickness of the skin layer was weekly measured by ultrasound images. The correlation between the thickness of the skin layer and the radiation energy density was analyzed by Pearson correlation analysis. Results: The thickness of the skin layer demonstrated a significant increase in the ۷th week of exposure during the injury process due to UV radiation, as compared to zero-day (P˂۰.۰۵). Furthermore, it showed a ۳۸ % increase in the ۷th week. The obtained results illustrated a significant correlation coefficient of more than ۰.۹۷ between the thickness of the skin layer and the energy density of UV radiation. Microscopic sections in the long-term UV-irradiated group confirmed trichoepithelioma. Conclusion: As evidenced by the obtained results, prolonged irradiation for ۹ weeks induced an animal model of trichoepithelioma.

نویسندگان

Mohadeshe Estaji

Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Manijhe Mokhtari-Dizaji

Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Mansoreh Movahedin

Department of Anatomy, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Sahar Ghaffari Khaligh

Department of Pathology, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran

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  • Nishisgori C. Current concept of photocarcinogenesis. Photochem Photobiol Sci. 2015; ...
  • Kammeyer A, Luiten RM. Oxidation events and skin aging. Ageing ...
  • Christensen L, Suggs A, Baron E. Ultraviolet photobiology in dermatology. ...
  • Salmaninejad A, Kangari P, Shakoori A. Oxidative stress: Development and ...
  • Liguori I, Russo G, Curcio F, Bulli G, Aran L, ...
  • Kabir S, Schmults C, Ruiz E. A review of cutaneous ...
  • Sharma MR, Werth B, Werth VP. Animal models of acute ...
  • D'Orazio J, Jarrett S, Amaro-Ortiz A, Scott T. UV radiation ...
  • Chen WJ, Chang YY, Shen SC, Tzeng YL, Lee HC, ...
  • Ahmadi Ashtiani HR, Hekmat Nazemi N, Rezazadeh S, Gholamhoseini B, ...
  • Wang XF, Huang YF, Wang L, Xu LQ, Yu XT, ...
  • Scott TL, Christian PA, Kesler MV, Donohue KM, Shelton B, ...
  • Raad H, Serrano-Sanchez M, Harfouche G, Mahfouf W, Bortolotto D, ...
  • Moon S, Youn J, Kim J. The effect of ultraviolet-B ...
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