Investigating the basis for the antidepressant effects of Gleditsiae spina using an integrated metabolomic strategy
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 24، شماره: 4
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 287
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شناسه ملی سند علمی:
JR_IJBMS-24-4_014
تاریخ نمایه سازی: 6 اردیبهشت 1400
چکیده مقاله:
Objective(s): Gleditsiae spina (GS) is a natural antidepressant but its mechanisms of action remain unclear. In the present study, taxifolin (Tax) was selected to determine the role of flavonoids in the antidepressant effects of GS.Materials and Methods: Urine samples from C۵۷BL/۶ mice were analyzed based on ultra performance liquid chromatography-quadrupole time of flight mass spectrometry (UPLC-Q/TOF-MS). Then, we investigated the therapeutic effects of GS and Tax in depression models in vivo. An integrated metabolomic approach was used to examine the metabolic profiles of GS/Tax groups and corticosterone model groups (Cor). Metabolic networks in response to GS/Tax treatment were established for the comparison of antidepressant activities.Results: Corticosterone exposure significantly increased serum levels of corticosterone but decreased serum levels of ۵-hydroxytryptamine and sucrose consumption (p <۰.۰۱). Treatment with GS and Tax improved all measured variables compared to those of the corticosterone-exposed group (p < ۰.۰۱). The antidepressant effects of GS and Tax involved the regulation of pentose and glucuronate interconversions, arginine and proline metabolism, phenylalanine metabolism, taurine and hypotaurine metabolism, and the citrate cycle.Conclusion: These findings indicate that flavonoids form the pharmacodynamic basis of the antidepressant effects of GS. Moreover, our findings highlight that integrated metabolomics provides a powerful tool to study the mechanisms and material basis of Chinese herbs.
کلیدواژه ها:
نویسندگان
Tong Liu
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China
Ning Zhou
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China
Yangang Cao
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China
Ruihao Xu
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China
Zhen Liu
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China
Xiaoke Zheng
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China
Weisheng Feng
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China
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