one -pot synthesis of 2H -pyridinyl -2-butenedioates in water

in this multicomponent reaction of dimethyl methoxymalonate 1 and dialky 1 acetylenedicarboxylates 2 in the presence of pyridine 3 processds smoothyl in water as a solvent at room temperature to produce dialkyl 2-2-2-methoxycarbonyl-2-oxoethylidene -12H-pyridinyl -2-butenedioated 4 in excellent yields schem1 structures of compounds were characterized on the basis of their elemental analyses and their IR , H NMR and C NMR spectra.

کلیدواژه ها:

multicomponent reactions ، one -pot synthesis ، dimethyl methoxymalonate ، 2H-pyridinl1-2-butenedioates ، …