Fe3O4@SiO2 Core-shell Sorbent for Magnetic Solid-phase Extraction and High-performance Liquid Chromatography Determination of Meloxicam in biological real samples

Fe3O4@SiO2 core-shell was synthesized and utilized for magnetic solid phase extraction (MSPE) followed by high-performance liquid chromatography (HPLC) quantitation of meloxicam in human plasma. The variables affecting the extraction yield involving as desorption conditions, pH of sample solution, dosage of sorbent, extraction time and salt content were studied and optimized. The calibration curve revealed linearity in the range of 20-750 ng mL-1 with regression coefficient corresponding to 0.990. Limits of detection (LOD, S/N = 3) and quantification (LOQ, S/N = 10) were 5 and 20 ng mL-1, respectively.

کلیدواژه ها:

Fe3O4@SiO2 core-shell ، high-performance liquid chromatography ، human plasma ، meloxicam