The Molecular Structure and Case Fatality Rate of COVID-19

سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 275

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شناسه ملی سند علمی:

JR_TUMS-2-3_006

تاریخ نمایه سازی: 17 فروردین 1400

چکیده مقاله:

A new coronavirus recognized as 2019 novel coronavirus (COVID-19) is the etiological cause in charge of the 2019-2020 viral pneumonia worldwide outbreak. The molecular structure and genome of this virus are identical to SARA-CoV and for an unknown reason, it is highly transmittable. The spike protein is responsible to attach to the host cell and viral single-stranded RNA (ssRNA) entrance to the cells. Upon binding of the Spike proteins to the host cell ACE2 receptor and merging with the membrane, COVID-19 ssRNA goes to the host cells. The viral RNAs are recognized as the foreign element by TLR3, TLR7, TLR8, and TLR9 in the host cell. The viral genome receptor retinoic-acid inducible, cytosolic receptor melanoma differentiation-associated gene, and nucleotidyltransferase cyclic GMP-AMP synthase (cGAS) is in charge of viral RNA representation in the cytoplasm.  Now there is no targeted therapeutics with high efficacies for the treatment of Covid 19 disease. More than usual medication some interfering RNA molecules are under debate.  The reason for being high transmission of COVID-19 is not recognized. This virus pandemic is now all over the world. 

نویسندگان

Zahra Sadat Aghamir

Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran

Sepideh Shivarani

Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Rima Manafi Shabestari

Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran

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  • 1. Brian D, Baric R. Coronavirus genome structure and replication. ...
  • 2. Lim WS. Influenza, pandemics and SARS. ERS Handbook of ...
  • 3. Zhu N, Zhang D, Wang W, Li X, Yang ...
  • 4. Jonsdottir HR, Dijkman R. Coronaviruses and the human airway: ...
  • 5. Snijder EJ, Van Der Meer Y, Zevenhoven-Dobbe J, Onderwater ...
  • 6. Hussain S, Chen Y, Yang Y, Xu J, Peng ...
  • 7. Sawicki SG, Sawicki DL, Siddell SG. A contemporary view ...
  • 8. Perlman S, Netland J. Coronaviruses post-SARS: update on replication ...
  • 9. Vankadari N, Wilce JA. Emerging WuHan (COVID-19) coronavirus: glycan ...
  • 10. Song W, Gui M, Wang X, Xiang Y. Cryo-EM ...
  • 11. Morimoto C, Schlossman SF. The structure and function of ...
  • 12. Letko M, Marzi A, Munster V. Functional assessment of ...
  • 13. Abdelmageed MI, Abdelmoneim AH, Mustafa MI, Elfadol NM, Murshed ...
  • 14. Chan YK, Gack MU. Viral evasion of intracellular DNA ...
  • 15. Guo Y-R, Cao Q-D, Hong Z-S, Tan Y-Y, Chen ...
  • 16. Huang C, Wang Y, Li X, Ren L, Zhao ...
  • 17. Organization WH. Clinical management of severe acute respiratory infection ...
  • 18. Liu C, Zhou Q, Li Y, Garner LV, Watkins ...
  • 19. Dong L, Hu S, Gao J. Discovering drugs to ...
  • 20. Lu H. Drug treatment options for the 2019-new coronavirus ...
  • 21. Martinez MA. Compounds with therapeutic potential against novel respiratory ...
  • 22. Dhama K, Sharun K, Tiwari R, Dadar M, Malik ...
  • 23. Totura AL, Bavari S. Broad-spectrum coronavirus antiviral drug discovery. ...
  • 24. Otter J, Donskey C, Yezli S, Douthwaite S, Goldenberg ...
  • 25. Zhang L, Liu Y. Potential interventions for novel coronavirus ...
  • 26. de Wit E, van Doremalen N, Falzarano D, Munster ...
  • 27. Sahin AR, Erdogan A, Agaoglu PM, Dineri Y, Cakirci ...
  • 28. Chen N, Zhou M, Dong X, Qu J, Gong ...
  • 29. Wang Z, Chen X, Lu Y, Chen F, Zhang ...
  • 30. COVID-19 Treatment Guideline Version 0.2- date: 18 march 2020 ...
  • 31. Baron SA, Devaux C, Colson P, Raoult D, Rolain ...
  • 32. Russell CD, Millar JE, Baillie JK. Clinical evidence does ...
  • 33. Hoffmann M, Kleine-Weber H, Krüger N, Müller M, Drosten ...
  • 34. Huang C, Wang Y, Li X, Ren L, Zhao ...
  • 35. Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Di ...
  • StatPearls Publishing LLC.; 2020. ...
  • 36. Chen L, Xiong J, Bao L, Shi Y. Convalescent ...
  • 37. Shanmugaraj B, Siriwattananon K, Wangkanont K, Phoolcharoen W. Perspectives ...
  • 38. Carthew RW, Sontheimer EJ. Origins and mechanisms of miRNAs ...
  • 39. Doench JG, Petersen CP, Sharp PA. siRNAs can function ...
  • 40. Xu J-z, Zhang J-l, Zhang W-g. Antisense RNA: the ...
  • 41. Mahase E. Coronavirus: covid-19 has killed more people than ...
  • 42. Moghadami M, Hassanzadeh M, Hedayati A, Malekolkalami M. Modeling ...
  • 43. Tuite AR, Bogoch II, Sherbo R, Watts A, Fisman ...
  • 44. Kokabisaghi F. Assessment of the effects of economic sanctions ...
  • نمایش کامل مراجع