Long non-coding RNAs as biomarkers in pancreatic cancer

Pancreatic cancer (PC) is one of the most common causes of cancer-related deaths worldwide. Considering the lack of effective biomarkers for predicting and diagnosing PC, the underlying mechanism is still steadily investigated but not fully understood. Non-coding RNAs (ncRNAs) are protein-free RNAs produced bygenome transcription; they have key functions in regulating gene expression, participating in epigenetic modification, cell proliferation, differentiation and reproduction. Long non coding RNAs (lncRNAs) contribute to biological functional diversity and complexity in protein regulatory networks.Scientific studies have confirmed the emerging functions and regulatory roles of lncRNAs in pancreatic cancer. It is necessary to know that some thorough studies have shown that lncRNAs are significantly associated with the onset and progression of PC. lncRNAs can be used to diagnose and treat pancreatic cancer and have significant potential for clinical application.

کلیدواژه ها:

long non-coding RNA ، pancreatic cancer ، biomarker