Multicomponent synthesis of new derivatives of thiazolidine-4-ones in the presence of bis ionic liquid DABCO-diactate as a green media

-4-ones exhibit antitubercular, antimicrobial, antioxidant and antifungal activity and can be applied as COX-1 inhibitor, bacterial enzyme MurB inhibitor, non-nucleozide anzyme inhibitor of HIV-RT and antihistaminic agent1 For this reason, synthesis of novel derivatives of thiazoline-4-ones have attracted a lot of interest. A multi-component reaction (MCR) can create highly complex molecules from readily available starting materials without complicated purification operations. Thus, MCRs are identified as time-effective, money saving, energy and raw material saving and economically favorable processes in diversity generation. They have benefits due to the creation of several new bonds in a one-pot reaction, a low number of reaction and purification steps, selectivity, synthetic convergence, high atom economy, simplicity and synthetic efficiency.2 On the other hand, ionic liquids are suitable alternative instead of toxic solvents and volatile chemicals in the chemical and pharmaceutical industries, due to their proper emission and conductivity, thermal stability, reparability and recovery, high polarity and environmental friendliness and used as the green catalyst for organic reactions.3In continuation of our previous work2,3, herein, we specifically address the synthesis and usage of bis ionic liquid 1,4-diazabicyclo[2.2.2] octanium diacetate as an environmentally friendly green media for the synthesis of azo-thiazolidine -4-ones.

کلیدواژه ها:

Multicomponent reactions ، ionic liquid ، azo-thiazolidine-4-one