One pot aqueous media synthesis of 1,3-oxazine derivatives catalyzed by reusable nano-Al2O3/BF3/Fe3O4 at room temperature

The distinctive aspect of multi-component reactions (MCRs) is that the products contain all parts of substrates, creating almost no by-products. So, the applications of MCRs are very popular with only a minimum of endeavor and offer a wealth of products.1 The 1,3-oxazine ring system has a structure which known as one of biologically-active heterocycles.2 In addition, realizing the importance of naphthoxine compounds which has alterative prospect for the treatment of Parkinson’s disease reported.3 Previously, some is shown in protocols for synthesis of various naphtho[1,3]oxazines via a Mannich type condensation between a 2-naphthol, formaldehyde and a primary amine were reported. In this work, we wish to report effective and eco-friendly procedure for the synthesis of 2-aryl/alkyl-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine in the presence of nano-Al2O3/BF3/Fe3O4. The obtained 1,3-oxazine compounds were characterized by various methods such as FT-IR, 1HNMR and melting point.4

کلیدواژه ها:

Nano-Al2O3/BF3/Fe3O4 ، 1 ، 3-Oxazine ، Magnetic catalyst ، Lewis acid catalyst ، Multi-component reactions.