Synthesis of amines through condensation of p-toluene sulphonamide with benzhydrol derivatives in the presence of copper-phosphine complexes

Amines employ an important role in biological, pharmacological and agricultural activities.1,2 Amongst them, diaryl containing amines because this structural motif can be found in several drugs such as cetirizine, sertraline, rasagiline and rivastigmine,3,4 which have attracted growing attentions. There are lots of various synthetic methods for the preparation of diarylamine, which amongst them arylation of aldimines employing various catalyst and aryl transfer reagents are realized due to high yield and activity. Because of the importance of carbon-nitrogen bonding in organic synthesis, the development of appropriate methods for the formation of these bonds is one of the most important goals of chemists.In this work, diarylamines 3 were synthesized using p-toluenesulfonamides 2 with benzhydrol derivatives 1 in the presence of copper/bisphosphine complex yielding >98% under clean and mild reaction conditions. Use of available and cost-efficiency copper salts, short reaction time, high yield and rate of reaction highlighted this method. The structure of products are investigated by melting point, IR, 1H NMR and 13C NMR spectroscopies

کلیدواژه ها:

Benzhydrol ، Amine ، Copper complex ، Phosphine ligand