Electrospinning of nanofibers based on carboxymethyl tragacanth-polyvinyl alcohol/nano-clay composite containing silver nanoparticals for wound healing applications

The present article discusses a simple method to prepare antibacterial carboxymethyl tragacanth (CMT)/ polyvinyl alcohol (PVA) nanofiber mats containing silver nanoparticles (Ag NPs).1 The nanofibers are fabricated by electrospinning of CMT/PVA/AgNO3 blend aqueous solution with an AgNO3 concentration of 10 mmol/L. Then the prepared composite was cross-linked with glutaraldhyde.2 In electrospinning procedure, the Ag NPs with average diameter of 4.5 nm are obtained and separated from each other on the surface of CMT/PVA nanofibers.3 At the next step nano-clay (NC) powder was added to the prepared nanocomposite structure with various mass ratio to enhance the chemical and mechanical stability of the prepared nanofibers. The prepared nanofibers are characterized by scanning electron microscopy (SEM), fourier transform infrared (FTIR) techniques. The formation and morphology of Ag NPs were investigated by Transmission Electron Microscopy and X-ray Photoelectron Spectroscopy. Finally, Ag release from the nanofibers was measured and the antibacterial behavior of the nanofibers against Escherichia coli was studied by bacterial growth inhibition halos and bactericidal kinetic testing. 4

کلیدواژه ها:

Electrospinning ، Carboxymethyl Tragacanth ، Polyvinyl Alcohol ، Silver Nanoparticles ، Wound Healing Applications