One-Pot synthesis of stable phosphorus ylides

Phosphorus ylides are reactive systems, which take part in many reactions of value in organic synthesis.1 The development of the modern chemistry of naturally and physiologically active compounds would have been impossible without the phosphorus ylides. These compounds have attained great significance as widely used reagents for linking synthetic building blocks with the formation of carbon-carbon double bonds, and this has aroused much interest in the study of the synthesis, structure, and properties of P-ylides and their derivatives.2 Several methods have been developed for the preparation of phosphorus ylides. They are usually obtained by treatment of a phosphonium salt with a base; phosphonium salts are usually prepared from the corresponding phosphines and an alkyl halide.3 Here we report an efficient synthetic route to stable phosphorus ylides using, arylglyoxals 1 and 1,3-dicarbonyl compounds such as barbituric acid 2 and triphenylphosphine 3 at boiling ethanol. All synthesized compounds are stable solids whose structures were determined on the basis of their 1H and 13C NMR and IR spectroscopic data.

کلیدواژه ها:

Phosphorus ylides ، Triphenylphosphine ، Arylglyoxals ، 1 ، 3-dicarbonyl compounds