Cellulose nanocrystals functionalized by folate-Conjugated cyclodextrin for targeted anti-cancer drug delivery system

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 304

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شناسه ملی سند علمی:

ISOC27_390

تاریخ نمایه سازی: 19 اسفند 1399

چکیده مقاله:

Targeted drug delivery systems (TDDSs) have been exploited to improve the efficacy of anticancer agents by increasing their concentration in tumor cells relative to normal cells.1,2 This leads to administration of required amount of drug with low toxicities which usually occur with conventional chemotherapeutic agents.3 Herein, a TDDS based on nanoparticles transaminase of nanocrystalline cellulose (CNCs) which was prepared for cancer cell targeting. The nanoparticles transaminase then conjugated with carboxymethyl-β-cyclodextrin (CM-β-CD). The folic acid (FA) was then embedded into CD cavity via host guest interaction. Doxorubicin (DOX) an anticancer drug was introduced into nanocarier spheres. The properties of the prepared nanocarier were characterized by FT-IR, scanning electron microscope (SEM) and TGA. The in-vitro drug release and drug loading capacity were measured using UV spectroscopy.

نویسندگان

Sedigheh Ehsanimehr

Department of Organic Chemistry, Faculty of Chemistry, Urmia University, Urmia, Iran

Peyman Najafi Moghadam

Department of Organic Chemistry, Faculty of Chemistry, Urmia University, Urmia, Iran