Release of Anticancer Sunitinib Drug from Chitosan Coated Magnetic Nanoparticle

The development of an effective method to treat advanced tumor infections remains a major challenge in cancer therapeutics.1 In order to reach high therapeutic effects and reduce the side effects, active drug molecules should selectively accumulate in the disease area for a prolonged period with high controllability. Drug delivery refers to the approaches, formulations, technologies, and systems for transporting therapeutics in the body as needed to safely and efficiently achieve their desired therapeutic effects.2 Sunitinib, an anticancer drug, released efficiently from magnetic carriers to acidic pHs environment. Considering that the nanoparticle size of magnetic carriers influences the release rate3 as well as the magnetic nanoparticle size affected by the amount of chitosan, in this project, magnetic chitosan nanocarrier used to the controlled release of sunitinib. The magnetic nanoparticles synthesized by a special method and the produced samples dried by freeze-drying. The structure of the produced nanocarrier characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM) techniques. The release behavior of chitosan-coated nanoparticles investigated and revealed a pH and depended release profile. It showed good release at acidic media and at 25°C temperatures, which employed the chitosan-coated nanoparticles as an effective carrier.

کلیدواژه ها:

Magnetic nanoparticle ، Chitosan ، Anticancer ، Drug delivery ، Sunitinib