Multi-component synthesis and study of biological properties of new di-amide's Ugi derivatives based on ibuprofen

Multicomponent reactions (MCRs) combine three or more reactants in a single operation to afford an adduct with a minimum loss of atoms.1 The development of multi-component reaction 2 protocols for the synthesis of heterocyclic compounds has attracted significant interest from pharmaceutical groups. The Ugi four-component reaction (Ugi-4CR) is useful isocyanide- based MCRs that allow easy access to structurally varied and complex intermediates or scaffolds.3 The use of water as a solvent for organic transformations offers several “green chemistry” benefits.4-5 The product is formed by the synthesis of di-amid from cyclohexyl isocyanide 1, aldehyde 2, benzylamine 3, ibuprofen 4 in room temperature and water used as solvent. The structures are determined on the basis of their mass spectrum 13CNMR, 1H-NMR, and IR spectroscopic data.

کلیدواژه ها:

Multicomponent reaction ، Ugi ، Green chemistry ، Isocyanides ، Di-amide ، Ibuprofen