Synthesis of N-(4-Chlorobutanoyl)-1,2-Dihydro-(4H)-3,1-Benzoxazin-4-one Derivatives

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 160

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شناسه ملی سند علمی:

ISOC27_366

تاریخ نمایه سازی: 19 اسفند 1399

چکیده مقاله:

3,1-Benzoxazin-4-one and their derivatives1,2 are versatile intermediates in the synthesis of heterocycles with high pharmacological and biological activities.3,4 Here, we report a practical and convenient synthesis of N-(4-chlorobutanoyl)-1,2-dihydro-(4H)-3,1-benzoxazin-4-ones by cyclization reaction of Schiff-bases 3 (produced by condensation reaction of anthranilic acid derivatives 1 with benzaldehyde derivatives 2 at room temperature) with 4-chlorobutanoyl chloride at room temperature (Scheme 1). The presence of Cl in the end of butanoyl chain, makes the produced benzoxazine-4-ones 4 more reactive for further reactions against nucleophiles. The structures of all synthesized compounds were determined on the basis of their spectroscopic data.

نویسندگان

Farzad Nikpour

Department of Chemistry, Faculty of Sciences, University of Kurdistan, Sanandaj, Iran

Jamal Azizi

Department of Chemistry, Faculty of Sciences, University of Kurdistan, Sanandaj, Iran