Highly efficient one-pot synthesis of N-(2,2-dicyanovinyl)-aniline in deep eutectic solvent

Alzheimer's disease (AD) is one of the most common diseases in the eldery. It is characterized by neuronal loss, synaptic damage, a deficit in neurotransmitter acetylcholine and vascular plaques. Still no precise explanation for the cause of this disease has yet been identified. The most recent method for the treatment of (AD) is suppresses acetylcholinesterase (AChE) to increase the acetylcholine (Ach) level in synapses. The available drug approved by the U.S food and Drug Administration (FDA) for the treatment Of AD are : Tacrine, Rivastigmine, Donepezil and Galantamine. One of the substance that is required for the synthesis of Tacrine is N-(2,2-dicyanovinyl)-aniline.1,2In this research, we applied choline chloride/urea based deep eutectic solvent (DES) for three component synthesis of N-(2,2-dicyanovinyl)-aniline by the reaction of aniline derivatives and malononitrile and trimethylorthoformate at 60 °C. using DES has many advantages such as non-toxicity, cleaner and easier work-up procedures. This DES can be recycled four times without decrease in activity.

کلیدواژه ها:

N-(2 ، 2-dicyanovinyl)-aniline ، Alzheimer's Disease ، Choline choloride/urea ، synthesis of Tacrine