Design, synthesis and application of Ch-MoO as an efficient catalyst for the synthesis of Hantzsch 1,4-dihydropyridines

In recent years, developing routs to produce materials based on green chemistry which minimizes pollution have been focused.1 For this purpose these goals, the development of heterogeneous catalysts in the synthesis of organic compounds is highly investigated due to the ease of handling, reusability and simple work-up. Therefore, immobilization of metal on inorganic support to produce heterogeneous catalytic systems has been widely reported. Recently, chitosan (Cs) as a biological polymer has been found to be the most abundant natural amino polysaccharide that is usually obtained by deacetylation of chitin. It has attracted significant interest due to its green properties, safety, non-toxicity, biocompatibility, biodegradability, low immunogenicity, stability and ability of chelation.In continuation of our efforts to synthesize of novel catalysts 2 for applying in the synthesis of heterocyclic ring, we wish to design and synthesis of molebdinium supported chitosan Ch-MoO as an efficient catalyst for the synthesis of 1,4-dihydropyridine through the condensation reaction of aldehydes, ethyl acetoacetate, ammonium acetate under solvent free condition at 80° C (Scheme 1).

کلیدواژه ها:

Chitosan ، 1 ، 4-dihydropyridines ، Hantzsch reaction