Synthesis of fused N-hetrocycle compounds as biologically drug candidates by using novel Zr-based MOFs with sulfonic acid tags

Polyfunctionally substituted nitriles are versatile reagents that have been extensively utilized as precursors for synthesis of functionalized heteroaromatic compounds.1 Development of the synthetic routes for these compounds is a great demand.2 2-Aminoprop-1-ene-1,1,3-tricarbonitrile (1) has proved to be an excellent precursor to condensed pyridines, pyridazines, and pyrazoles.3 Herein, we wish to report novel Zr-based metal organic frameworks (MOFs) with sulfonic acid tags as a nonporous catalyst. 6-Amino-2-(dicyanomethylene)-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitriles were prepared by reaction of 2-aminoprop-1-ene-1,1,3-tricarbonitrile (1), aldehyde and malononitrile in the presence of Zr-MOFs-SO3H at 110 ◦C in excellent yields and short reaction times (Fig 1).

کلیدواژه ها:

Malononitrile dimer ، N-Hetrocycle derivatives ، Zr-based MOFs with sulfonic acid tags.