Synthesis of fused benzoquinolines:Catalytic application of Co-phthalocyanine-SO3H

N-Heterocyclic compounds are a paramount important class of biological and medicinal candidates.1 These scaffolds are found to be having several applications in agrochemicals, pharmaceuticals, dyestuffs, and functional materials. They have a wide range of biological activities including antitubercular, anticancer, antipsychotic, antimicrobial, anti-HIV, and for the treatment of neurodegenerative diseases.2 Marinoquinolines are a class of fused quinolines isolated from the marine bacteria having antibacterial and antifungal activities. Fused quinolines and benzoquinolines core units are found in various alkaloids and commercial drugs.3 In this work, we wish to report a clean method for synthesis of benzoquinoline derivatives via reaction of aromatic amin, dimedone and aryl aldehyde under refluxing CH3CN using Co-phthalocyanine-SO3H (10 mg) as an efficient nano-catalyst (Scheme 1).

کلیدواژه ها:

Benzoquinoline ، Co-phthalocyanine-SO3H ، Three-component reaction