[Bmim]HSO4 loaded on graphene oxide: a green, reusable and nanocatalyst for the synthesis of polysubstituted pyrroles

Polysubstituted pyrroles are of paramount importance due to their antibacterial,1 antiviral and antitumor,2 antioxidant3 activities and ability to inhibit the cytokine-mediated diseases.4 Mention above and in course of multicomponent reactions (MCRs), one of the most important of MCRs is the synthesis of polysubstituted pyrroles.In this research paper, a simple and convenient method for the synthesis of various polysubstituted pyrroles using mixture of the amines such as arylamines, 2-amino-4-methyl thiazole, adenine, aryl aldehydes, 1,3-dicarbonyl compounds and nitromethane in the presence of [Bmim]HSO4 / GO as a green, reusable and nanocatalyst (Scheme 1).The advantages of this protocol are the synthesis of some unprecedented polysubstituted pyrroles having fluorine atom and, containing thiazole and adenine nuclei that are very important in pharmaceutical and drug discovery research.

کلیدواژه ها:

Graphene oxide ، Pyrroles ، Multicomponent ، [Bmim]HSO4 / (GO)