Intramolecular Diels–Alder and [3+2] Cycloaddition Reactions in the One-Pot Synthesis of Epoxypyrrolo[3,4-g]indazoles
محل انتشار: بیست و هفتمین کنفرانس شیمی آلی ایران
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 204
نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
ISOC27_072
تاریخ نمایه سازی: 19 اسفند 1399
چکیده مقاله:
Diels–Alder and [3+2] cycloaddition reactions are two dynamic tools for synthesis of diverse organic compounds. Recently employment of IMDA reaction in acetylene based isocyanide multicomponent reactions has found remarkable interests.1 Additionally, in continuation of our previous works in acetylene-based isocyanide multicomponent reaction,2 we were interested in the reaction of isocyanides 1, dialkyl acetylene dicarboxylates 2 and 2-furan carboxylic acid 3, which led to 1,3-dioxoepoxyisoindoles 4. In the next step, we decided to investigate the reactivity of the double bond in the structure of 1, 3-dioxoepoxyisoindole 4 toward [3+2] cycloaddition reaction. To achieve this goal, hydrazonoyl chloride 5 with an equivalent amount of triethylamine were added to the reaction mixture and the reaction outcome was the epoxypyrrolo[3,4-g]indazoles 6/6ʹ in the form of two diastereomers, products were verified by mass, IR, 1H NMR, 13C NMR spectra and X-ray crystallography.
کلیدواژه ها:
نویسندگان
Abdolali alizadeh,
Department of Chemistry, Tarbiat Modares University, Tehran, Iran
Behnaz Farajpour,
Department of Chemistry, Tarbiat Modares University, Tehran, Iran
Kaveh Amir Ashjaee Asalemi
Department of Chemistry, Tarbiat Modares University, Tehran, Iran