Triethylammonium thiolate as an efficient reagent for synthesis of quinoxaline containing indandione skeleton via sequential one-pot multicomponent reaction

The nitrogen-containing heterocyclic compounds containing quinoxaline motif are well known for their biological activity1. So far, many synthetic methods have been reported for the preparation of quinoxalines. Most of these methods are conducted under harsh reaction conditions such as using acidic catalysts and oxidant reagents, reflux conditions, and microwave irradiation2.Considering the biological properties of the compounds containing quinoxaline and indandione skeleton (Indandione motif was found in pharmaceutical compounds and natural products3]), we introduce the synthesis method of novel derivatives of 3-hydroxy-2-(3-phenyl-quinoxalin-2-yl)-1H-inden-1-ene 5 via a sequential one-pot three-component reaction between new triethylammonium thiolate salts 3, methyl iodide and o-phenylenediamines 4 in EtOH at room temperature

کلیدواژه ها:

Triethylammonium thiolate ، Methyl iodide ، O-Phenylenediamine ، Quinoxaline ، Indandione motif ، Multicomponent reactions