Synthesis and catalytic application of a novel phosphonium based ionic liquid for the preparation of pyridine derivatives

Phosphonium-based ionic liquids (PILs) represent varied merits such as more thermal and chemical stability, over other types of ionic liquids such as imidazolium and pyridinium-based ionic liquids. Therefore, PILs have varied applications in academic and industrial processes1.On the other hands, improvement of the reaction efficacy, atom and step economy, synthesis of complex molecules through a simple route, reduction of waste production and avoidance of utilization of hazardous organic solvents have become crucial issues for chemists. Multicomponent reaction strategy, can resolve these concerns2.One of the most important scaffolds of heterocyclic structures is pyridine systems. The versatile molecules can be found in several pharmaceutical active structures. It is reported that some pyridine derivatives applied as IKK-b inhibitors, A2A adenosine receptor antagonists, inhibitor of HIV-1 integrase3.In this work, we reported the synthesis and catalytic application of a novel phosphonium based ionic liquid for the preparation of pyridine derivatives under mild reaction conditions

کلیدواژه ها:

Phosphonium-based ionic liquids ، Pyridine derivatives ، Multicomponent reactions ، Cooperative vinylogous anomeric based oxidation