DISTRIBUTION OF GENES ENCODING RESISTANCE TO MACROLIDES, LINCOSAMIDES, AND STREPTOGRAMINS AMONG METHICILLINRESISTANT STAPHYLOCOCCUS AUREUS STRAINS ISOLATED FROM BURN PATIENTS

سال انتشار: 1399
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 152

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شناسه ملی سند علمی:

AVAN01_017

تاریخ نمایه سازی: 5 بهمن 1399

چکیده مقاله:

Background: The increasing resistance to macrolide, lincosamide, and streptogramin B agents among methicillin-resistant Staphylococcus aureus (MRSA) is a worldwide problem for the health community.Methods: This study aimed to investigate the prevalence of ermA, ermB, ermC, and msrA in MRSA strains isolated from burn patients in Ahvaz, southwest of Iran.Finding: A total of 76 isolates of S. aureus were collected from January to May 2017 from Taleghani Burn Hospital in Ahvaz. Among 76 S. aureus strains collected, 60 (78.9%) isolates wereMRSA.The antimicrobial susceptibility testing forMRSA showed extreme high resistance rate to clarithromycin (100%) and azithromycin (100%), followed by erythromycin (98.3%). The PCR assay revealed that the frequency rates of msrA, ermA, and ermC genes were 23 (38.3%), 28 (46.7%), and 22 (36.7%), respectively.Conclusion: In addition, none of the MRSA isolates had the ermB gene. Because of the high prevalence of macrolide and lincosamide resistance found in MRSA isolates from infections of burn patients in Ahvaz, southwest of Iran, it is recommended that local periodic survey be performed for controlling the dissemination of antimicrobial resistance.

نویسندگان

maryam moradi

School of Bacteriology, Ahwaz Jundishapur Medical School, Head of Medical Microbiology, School of Medicine, Ahwaz Jundishapur University

saeed khoshnood

School of Bacteriology, Ahwaz Jundishapur Medical School, Head of Medical Microbiology, School of Medicine, Ahwaz Jundishapur University