A review on fabrication of 3D scaffolds for cartilage tissue engineering

A disease known as Osteoarthritis is spreading around world, especially in developing countries. According to the World Health Organization (WHO), nowadays about 355 million people suffer from joint disease worldwide, of these, 190 million people are with osteoarthritis and more than 16.5 million people are suffer from rheumatoid arthritis. Since the cartilage of a tissue has no veins is not capable of repairing and regenerating. Damages caused by cartilage tissue corrosion lead to crepitus and the patient suffers a lot of pain. Use of the patient's own chondrocytes, stimulation of bone marrow and removal of the damaged tissues are treatment techniques, but they are not deterministic treatment ones. Tissue engineering and fabrication of scaffolds containing biological materials could be a new prospect on cartilage tissue treatment. In this study tries to demonstrate the properties for cartilage tissue treatment by introducing 3D bioprinting technique and using biocompatibility materials such as Chitosan, Gelatin, Calcium Alginate, etc. The use of electrospun nanofibers or nanoparticle composites in 3D bioprinting is also increasing every day. The results of conducted studies indicate that the use of three-dimensional scaffolds could have more effects on repairing the cartilage tissue.

کلیدواژه ها:

3D bioprinting ، Electrospinning ، Cartilage Tissue Engineering ، Chitosan ، Gelatin ، Nanoparticles