Replacement in animal researches, a review article

Introduction: Replacement methods are a vital one of the three Rs of animal testing alternatives because they completely replace the animal model with a non-animal method of testing. Alternatives to animal experiments are procedures which can completely replace the need for animal experiments, reduce the numbers of animals required, or diminish the amount of pain or distress suffered by the animals in meeting the essential needs of man and other animals.In this study, using google scholar and reviewing numerous articles, different alternatives to animal researches are considered.Description: Here are some alternatives to animal in scientific researches: “Organ – on – chips”, containing human cells grown in a state-of-the-art system to mimic the structure and function of human organs and organ systems, MatTek’s epiderm Tissue Model—a 3-dimensional, human cell–derived skin model that replicates key traits of normal human skin to assess skin allergy, devices made by German-base manufacturer VITROCELL are used to expose human lung cells in a dish to chemicals in order to test the health effects of inhaled substances, different tests that use human blood cells to detect contaminants in drugs that cause a potentially dangerous fever response when they enter the body, a wide range of sophisticated computer models that simulate human biology and the progression of developing diseases, Quantitative structure-activity relationships (QSARs) which are computer-based techniques that can replace animal tests by making sophisticated estimates of a substance’s likelihood of being hazardous, researches With human volunteers such as “microdosing” and Advanced brain imaging and recording techniques such as “MRI”, human-patient simulators such as “Trauma man”.Discussion & Conclusion: Given the global approach to respect for animal rights in medical research, it seems that in our country, it is necessary to pay more attention to animal rights by trying new technologies.

کلیدواژه ها:

Replacement ، Alternatives ، Animal research ، Animal rights