An implantable smart electrospun nanofibers with switchable drug release for hyperthermic tumor cell treatment

A smart polymeric electrospun nanofibers is described with concurrent heat generation and drug release in response to ‘on-off’ switching of alternating magnetic field (AMF) for induction of breast cancer apoptosis. The smart hyperthermia electrospun nanofibers are constructed via electrospinning temperature-responsive copolymer of NIPAAm and N-hydroxymethylacrylamide (HMAAm) (poly (NIPAAm-coHMAAm)) blended with magnetic nanoparticles (MNPs) and Cur. The prepared electrospun nanofibers characterized by Fourier transform infrared (FTIR) spectroscopy, 1H nuclear magnetic resonance (1H-NMR) spectroscopy and scanning electron microscopy (SEM). Correspondingly, the Cur loading efficiency and in vitro drug release of Cur from nanofibers were investigated by AMF and without magnetic field effect. The antitumor activity of synthesized nanofibers was also investigated on the breast cancer MCF7 cell lines. In vitro anti-tumor studies demonstrated that both MNP- and Cur-loaded nanofibers killed about 66% of cells, whereas only Cur-loaded nanofibers killed about 43% of cells. Therefore, an implantable smart magnetic nanofiber device can be used to both apply hyperthermia with AMF and to achieve cancer cell-specific drug release to enable synergistic cancer therapy. Taken together, our results not only provide an innovative smart magnetic nanofibers system as stimuli-responsive, synergistic chemo-thermal therapy platform for efficient reduction in the recurrence of breast cancer, but also achieve insight into the intricate interplay of the functional components in magnetic electrospun nanofibers.

کلیدواژه ها:

Curcumin ، Hyperthermia ، Chemotherapy ، Magnetic nanofiber