Construction of Multi-Component Scaffold Consisting of DNA Building Blocks and Aptamer Base on DNA Self-Assembly

Many studies have focused on DNA nanostructures for drug delivery; however, they have encountered many challenges and drawbacks including; destruction by nuclease, cell absorption problem and not being able for epithelial transmission. In spite of these problems, there are some techniques that can help us to address this problem. Therefore, we designed a tetrahedron which easily can be made by DNA self-assembly which has some beneficial characteristics like biocompatibility, ability for cell uptake and being programmable. Besides, in order to have higher rate of stability, we added four aptamer strands on the designed tetrahedron that can strengthen its functionality.

کلیدواژه ها:

Dynamic DNA Nanotechnology ، Self-Assembly ، Tetrahedron