Application of Piezoelectric nanobiomaterials in regenerative medicine and cancer therapy

Introduction: Piezoelectric materials are special kinds of materials which they exchange mechanical stress to electrical charge and vice versa. Due to their unique properties, piezoelectric materials have been founded extremely vast applications in the fields of electrical, ultrasonic, robotics, energy conversion, medicine, space, domestic industries, and many others.Description: owing to the polar nature of proteins and other structural components of cells, electrical field can use as a special tool for changing stem cells fate. Also, researches had shown previously that stem cells react to the mechanical stimulation through their receptors, which this phenomenon called as mechanotransduction. Accordingly, using piezoelectric materials in regenerative medicine can create new opportunities for preparing smart materials. Also, researches showed that by applying nanotechnology for building new biological structures, they can improve their biofunctionality of the engineering of tissues and also cancer-targeting systems. Accordingly, by using piezoelectric nanomaterials the ability for accelerating stem cell differentiation maybe prepared. Also, they can activate by both electrical and mechanical stimulation for guiding stem cells to our desire functional mature cells or releasing drugs for overcoming cancer cells.Discussion and conclusion: piezoelectric nanobiomaterials are multifunctional nanobiomaterials, which can be applied for advanced smart systems in tissue engineering scaffolds and cancer targeting systems.

کلیدواژه ها:

piezoelectric ، nanobiomaterials ، tissue engineering ، cancer therapy