The effects of selenium and probiotics co-supplementation on glycemic status and PPAR-γ gene expression in patients with gestational diabetes mellitus: a randomized, double-blind, placebo-controlled trial

Aim: The aim of this study was to determine the effects of selenium and probiotic co-supplementation on glycemic status and PPAR-γ gene expression in patients with gestational diabetes mellitus (GDM).Methods: This randomized, double-blind, placebo-controlled clinical trial was performed in 51 patients with GDM. Participants were randomly divided into two groups to take either probiotic containing Lactobacillus acidophilus, Bifidobacterium bifidum, and Bifidobacterium longum (2×109 CFU/day each) plus 200 μg/day selenium (n=26) or placebo (n=25) for 6 weeks. Results: Selenium and probiotic significantly decreased fasting plasma glucose (β -3.96 mg/dL; 95% CI, -6.54, -1.37; P=0.003), insulin concentrations (β -1.24 μIU/mL; 95% CI, -2.03, -0.46; P=0.002) and insulin resistance (β -0.38; 95% CI, -0.60, -0.17; P=0.001), and significantly increased insulin sensitivity (β 0.008; 95% CI, 0.003, 0.01; P=0.003) when compared with placebo. This combination also upregulated peroxisome proliferator-activated receptor gamma (PPAR-γ gene expression) (P=0.01) expression levels.Conclusion: Selenium and probiotic co-supplementation during 6 weeks to patients with GDM had beneficial effects on metabolic status and gene expression related to insulin metaboliam.

کلیدواژه ها:

Selenium ، probiotics ، gestational diabetes mellitus ، glycemic status ، PPAR-γ