LncRNAs Role in of Glioblastoma Multiform Carcinogenesis

Introduction: Glioblastoma multiform (GBM) is of the most invasive and most frequent cancer of primary brain origin. Treatment of GBM is still an important challenge. Despite the high risk that patients face when undergoing aggressive therapies such as surgery, radiation therapy, and chemotherapy, GBM remains difficult to treat, with an average survival of 14 months. However, the exact underlying mechanisms of GBM pathogenesis are not clear yet. Thus, there is an urgent need to indicate promising potential diagnostic and prognostic biomarkers in GBM patients.Description: the RNA-seq, miR-seq, and clinical data of GBM were retrieved from the TCGA database. The “DESeq2” package in R software was used to determine the differentially expressed genes. For in silico functional analysis, GO and KEGG signalling pathways were used.Discussion and conclusion: The data indicated that 377 lncRNAs, and 220 miRNAs were differentially expressed in GBM. The GO and KEGG pathway analysis has been shown that the differentially expressed mRNAs were primarily enriched in important signalling pathways in cancer.Taken together, data showed the prominent differentially expressed mRNAs, lncRNAs, and miRNAs in GBM. Our data suggested desired lncRNAs in the tumorigenesis of patients with GBM.

کلیدواژه ها:

glioblastoma multiform ، Tumorigenesis ، Long non-coding RNAs ، miRNA