Medicine Release from polymeric package and antimicrobial effects of produced Nano-fibers with Polycaprolactone/ chitosan in Breast Cancer

In this study, modeling of a controlled drug delivery system for release of dissolved drug in a polymer matrix through polymer degradation was investigated. This system is presented in plate format. The drug, with diffusion mechanism, is released into the environment through polymer degradation. Therefore, considering the basic purpose of this research, which is modeling, the fundamental equations of mass transfer governing the system were investigated. By numerical solution of these equations with artificial neural network, the kinetics of drug release from the system was obtained by polymer degradation kinetics. For careful consideration, the equations are plotted and discussed in terms of time. For the pure phase of PCL, no degradation occurs and drug release is based on two phases of sudden release and diffusion. In the pure phase PLGA degradation observed both in the polymer concentration graph and in the release profile, therefore, drug release is based on three stages of sudden release, release as a result of polymer degradation and diffusion. In order to blend the two phases, polymer degradation for the PLGA phase was well represented in the release profile, and we still see three-step release.

کلیدواژه ها:

Polymer ، Tamoxifen ، Breast Cancer