Viruses as Nanobiocarriers for Gene therapy

Viral vectors, bionanopar cles with diameters of ~100 nm or less, have long been proven to be the most efficient and stable transgene vectors into the cell and thus are suitable for vaccine and gene therapy. Viruses have increasingly been used in materials science, engineering, electronics, and nanotechnology. Here we discuss about viruses as tools and building blocks for gene therapy in biomedical science. Numerous researches use viral vectors as gene delivery systems, for vaccination, cancer and genetic disorders treatment. In a more efficient and persistent strategy, viral vectors have been used in anti-sensegene strategies through interfering RNA and splicing alteration as a powerful tool for correcting mutation.

کلیدواژه ها:

Bio-nanostructurs ، RNA interference ، U7 snRNA ، Exon skipping ، Gene therapy ، Viral Vectors