An expedient synthesis of novel derivatives of triazolo[3,4-b]quinazolins using HAp-encapsulated γ-Fe2O3-supported dual acidic heterogeneous nanocatalyst

Nowadays, designing and formulation of fast and facile organic reactions, which target products can be easily separated and purified in high yields, are significant purposes in current drug discovery. Heterocyclic compounds have various biological activities which are essential and needed for everyday life. Among heterocyclic compounds, quinazolines have a broad scope of pharmacological and biological activities such as anticancer, antitumor, antidiabetics and anti-inflammatory activity[1]. Very recently and in continuation of our continuous research program on the development of new catalysts for the promotion of the organic transformations, we have reported the preparation of [Fe2O3@HAp]-supported dual acidic nanocatalyst and its application for the synthesis of polyhydroquinoline derivatives [2,3](Fig. 1).This study addresses, the introduction of [Fe2O3@HAp]-supported dual acidic nanocatalyst as a highly powerful nano-catalyst for the simple and efficient synthesis of triazoloquinazolinone derivatives. The obtained results show that this method is convincingly superior to other reported procedures in terms of the reaction times and yields. Simple experimental procedure and use of a reusable catalyst with lower loading are other advantages of this method. Furthermore, this process avoids problems associated with organic solvents and liquid acids used, which makes it a useful and attractive strategy in view of economic and environmental advantages.

کلیدواژه ها:

triazoloquinazolinone ، multi-component ، [Fe2O3@HAp]-supported dual acidic nanocatalyst