Evaluation of biochemical –hematological parameters and thyroid hormones (TSH, T4, T3) in Thalassemia minor patients

Background: β-thalassemia is one of the most common disorders and blood diseases that are genetically transmitted from generation to generation. One of the common types of diseases with anemia is β-thalassemia minor. This research was based on the alteration to measure these indicators in differentiating patients with thalassemia minor of others, especially iron deficiency anemia as a screening test. Methods In this case-control study, samples of thalassemia minor (40) and healthy subjects (30) referring to Ali Asghar Hospital (Tehran) in 1396 were evaluated for Biochemical status (Fe, TIBC, Ca, Na, K, ALT, AST), Hematological (Hemoglobin, Hematocrit, Ferritin, MCV, MCH, MCHC) and Thyroid hormones (T3, T4, TSH). Then, using SPSS software, statistical tests were performed using independent T-Test and logistic regression and comparison of means. Results: The results of TIBC(1486.546±96.158 in case and 274.243±7.146 in control), Fe(249.491±11.667 in case and 91.950±7.335 in control), Ferritin(228.250±15.962 in case and 22.900±1.516 in control) showed that there was a significant difference in patients group in comparison with healthy subjects. Also, results showed that thyroid dysfunction was not significantly different in patients and also was not significantly different in other tests compared to healthy subjects. Conclusion: The following of determination of biochemical - hematological parameters and thyroid factors in thalassemia patients every year and the importance of regular follow up of β-thalassemia patients for early detection and proper treatment of complications and disease control in the community.

کلیدواژه ها:

β-thalassemia minor ، biochemical tests ، hematological parameters ، thyroid hormones