The role of G-protein receptor 30(GPR30) in spatial learning and memory task in young female rats receiving marijuana

Background and Aim : : sex-dependent differences in the abused drugs effects on mammalian behavior. There is an unknown effect of marijuana in neurological functions in people when taken in chronically. In the some study suggested that tolerant to the effect of chronic THC on performance behavior in female rats dependent to the present of ovarian hormones and the age of initiation use. The findings demonstrate that estradiol can exert its effects on cognitive performance via specific receptors.. Recently, a novel G-protein coupled receptor (GPR30) was described to mediating estrogen signaling in various cell lines.Methods : : fifty-four rats were randomly allocated to 9 groups. The E2,G1 and G15(every 4 days) and marijuana(every day), either individual and combine, were given intraperitoneally for 21 days and Morris water maze (MWM) test were performed after end of the injections. All groups were compared to control and vehicleResults : : In this study the role of GPR30 were investigated in spatial learning and memory task in female rats receiving marijuana. . The result of intra-peritoneal injection of estrogen and G1(GPR30 agonist) and G15 (GPR30antagonist),either individual and combine, showed that G1 alone significantly increase spatial learning however have no effect on memory. The result of intra-peritoneal injection of estrogen and E2 and G15(GPR30antagonist),either individual and combine, shown no effect on learning and memory. In addition, the results indicated that marijuana and marijuana plus G1 and marijuana plus G15 showed no effect.Conclusion : marijuana and estrogen either individual in long term don’t effect on spatial learning and memory task in young female rats, however, G1 alone has a non-specific positive effect on learning and memory.

کلیدواژه ها:

GPR30 ، spatial learning and memory ، marijuana