The importance of Circular RNAs in early diagnosis and development of novel therapeutic approach in neurodegenerative disorders

Background and Aim : Circular RNAs (circRNAs) are a class of long noncoding RNAs (ncRNAs) that are characterized by the presence of covalently linked ends and have been found in all life kingdoms. Here, we summarize classification, characteristics, biogenesis, and regulatory functions of circRNAs in Neurological Disorders. CircRNAs do not distribute equally in the neuronal sections in the brain, but mostly enriched in the synapses. These ncRNA can be used as potential clinical biomarkers in complex disorders of the central nervous system (CNS), which is supported by recent findings.Methods : In this review we gathered data from Scopus, Embase, Science Direct and NCBI databases. 53 papers were retrieved by limiting the search results to a specific time-frame. 10 papers were included in the review process, which meet our criteria.Results : Investigation of regulatory role of circRNAs will shed novel light in gene expression mechanisms during development and disease conditions and may identify circRNAs as new biomarkers for neurodegenerative disorders.Conclusion : Although circRNAs have potential value as non-invasive clinical biomarkers for CNS disorders, a considerable amount of future work remains to be invested. It is important to precisely identify with high sensitivity which circRNAs are specifically deregulated in disease conditions.

کلیدواژه ها:

Circular RNAs ، Biomarkers ، Neurodegenerative Disorders and Novel therapeutic approach