The Effect of Curcumin on Epilepsy Disorder Treatment: Systematic Review

curcumin is a yellow-orange dye obtained from turmeric, the powdered root of CURCUMA longa. Curcumin appears to possess aspectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes. Epilepsy a disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Treatment means thatthe use of drugs, exercise, etc. to cure a person of an illness. Materials and Methods: We searched PubMed and Google Scholar search engine with acute key words curcumin and epilepsy disorder and treatment . As a result, 47 articles were found respectively. All articleswere published between 2013 until 2018 and have ethical considerations. After investigating the titles, 24 were excluded and by reading abstracts11 articles excluded and 6 articles excluded by method investigating. At the end of reading 6 articles was included. Results: twoarticles of these studies revealed that curcumin has the potential role to prevent harmful effects of arsenic on neurogenesis. The other study shows that curcumin has anti-inflammatory effect due to epilepsy, and reduces neuronal loss hippocampus. One study stated thatcurcumin supplementation decrease in the expression of pro inflammatory cytokines. But, another article results indicates, oral curcumin treatment had no effect on chronic seizures, possibly because it wasn’t at adequate levels on that study. And the last study shows that, thechronic seizure reduced in patients who got curcumin, also nitrite and nitrate levels significantly decreased in their blood sample. Conclusion: Until now in most of the studies on this topic have the low number of patients. And we can get more reliable results, if more studiestend to this field. As a result, I think curcumin can be a neuroprotective agent with strong therapeutic potential in some neurological disorders, especially in epilepsy disorder.