Anti-VZV IgG antibody and hs CRP levels correlate with progression of coronary artery atherosclerosis
- سال انتشار: 1398
- محل انتشار: سیزدهمین کنگره بین المللی میکروب شناسی بالینی استاد البرزی
- کد COI اختصاصی: ICCM13_073
- زبان مقاله: انگلیسی
- تعداد مشاهده: 561
نویسندگان
artment of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Cardiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
artment of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
artment of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
Background and Objectives: The relationship between high levels of anti-Varicella Zoster Virus (VZV) IgG antibody in cerebrospinal fluid (CSF) and cerebrovascular atherosclerosis commends a possible similar association in other vessels. We aimed to investigate the association of VZV-seropositivity with coronary artery atherosclerosis.Materials and Methods: We recruited 88 newly diagnosed patients with more than 50% stenosis in at least one of the main coronary arteries. As the control group, 99 age-matched individuals with normal/insignificant coronary artery findings were included. Clinical, paraclinical and demographical data were gathered at the time of sampling. High sensitivity (hs) CRP levels were measured by nephelometry. VZV-seropositivity was determined by measuring of anti-VZV IgG antibody level in plasma. Multivariable logistic regression was used to evaluate the correlation of data with coronary vascular atherosclerosis. Results: The frequency of VZV-seropositivity was significantly higher in the atherosclerosis group compared to the controls (OR=1.88; 95%CI=1.03-3.44). The plasma levels of anti-VZV IgG antibody were significantly higher in patients with atherosclerosis (Median=2.70, IQR=1.53-4.30 AU/mL) than in the controls (Median=2.10, IQR=1.70-3.10 AU/mL, p=0.034). HsCRP levels in patients and controls were 5.19±2.00 and 1.51±1.07 mg/L, respectively. A correlation between hsCRP and anti-VZV IgG antibody level in plasma was observed (r=0.40, p< 0.001). The levels of hsCRP and anti-VZV IgG antibody increased based on the number of diseased vessels but only the difference in hsCRP levels reached a significant level (p< 0.001 and p=0.168, respectively). Conclusion: Our data suggest that VZV-seropositivity and hsCRP elevation jointly increase the risk of atherosclerosis. Multifactorial nature of atherosclerosis, however, leaves more options for the inflammatory milieu to be generated.کلیدواژه ها
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